STAT3 Inhibitor Peptide

STAT3 Inhibitor Peptide

from 99.00
STAT3 Inhibitor Peptide
 
Ac-PpYLKTK-OH
 
A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5. Supplied as a trifluoroacetate salt.
Cat No: CP794
Peptide Sequence Ac-Pro-Tyr(PO3H2)-Leu-Lys-Thr-Lys-OH
Molecular mass 870.9
Protect from Light Yes
Hygroscopic Yes
Packaged under inert gas Yes
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C38H63N8O13P
Storage -20°C
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