Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable

Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable

from 140.00
Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable
 
HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH2
 
A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin.
Cat No: CP791
Peptide Sequence H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH2
Molecular mass 3997.8
Protect from Light Yes
Hygroscopic Yes
Packaged under inert gas Yes
Cell Permeable: Yes
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C188H291N53O40S2
Storage -20°C
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