ERK Activation Inhibitor Peptide II, Cell-Permeable

ERK Activation Inhibitor Peptide II, Cell-Permeable

from 134.00
ERK Activation Inhibitor Peptide II, Cell-Permeable
 
MTPTAT-G-MEK113, H-GYGRKKRRQRRR-G-MPKKKPTPIQLNP-NH2
 
A cell-permeable 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that is fused to the HIV-TAT membrane translocating peptide (MTP) sequence via a glycine linker. Acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 210 nM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 29 µM). Does not affect the activation of JNKs or p38.
Cat No: CP789
Peptide Sequence H-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
Molecular mass 3146.8
Protect from Light Yes
Hygroscopic Yes
Packaged under inert gas Yes
Cell Permeable: Yes
Purity ≥95% by HPLC
Solubility DMSO or H2O
Chemical formula C136H241N53O31S
Storage -20°C
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