ERK Activation Inhibitor Peptide I, Cell-Permeable

ERK Activation Inhibitor Peptide I, Cell-Permeable

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ERK Activation Inhibitor Peptide I, Cell-Permeable
 
Ste-MEK113, Ste-MPKKKPTPIQLNP-NH2
 
A cell-permeable stearated 13-amino acid peptide corresponding to the N-terminus of MEK1 (MAPKK) that acts as a specific inhibitor of ERK activation and blocks the transcriptional activity of Elk1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). Potently blocks ERK activation in PMA-stimulated NIH 3T3 cells and NGF-treated PC12 cells (IC50 = 13 µM). Does not affect the activation of JNKs or p38.
Cat No: CP788
Peptide Sequence Ste-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
Molecular mass 1757.3
Protect from Light Yes
Hygroscopic Yes
Packaged under inert gas Yes
Purity ≥95% by HPLC
Solubility DMSO or H2O
Chemical formula C86H153N19O17S
Storage -20°C
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