DOTA-Octreotides are a group of compounds comprising DOTA, a metal chelator that carries a radionuclide and octreotide (an octapeptide that is a potent somatostatin (SST)) analog (where DOTA is tetra-aza-cyclododecane-N N’N’’N-’’’-tetra-acetate). Replacement of Phe by Tyr has been shown to increase affinity of DOTA-Octreotide radioconjugates to SST2-positive tumors both in-vitro and in-vivo. This form also has moderately high affinity for SST5 and intermediate affinity for SST3. Studies have shown therapeutic benefits including antimitotic effects and symptomatic cure of malignant insulinomas and gastrinomas.
Cat No:
CP4002
Peptide Sequence
DOTA - D - Phe - Cys - Tyr - D - Trp - Lys - Thr - Cys - Thr - ol (Disulfide bridge: 2 - 7)
Molecular mass
1421.6
Protect from Light
Yes
Packaged under inert gas
Yes
Purity
≥95% by HPLC
Solubility
H2O
Storage
-20°C
Title:
Quantity:
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Advanced Peptides
Custom Peptides, Libraries, Antibodies, and PNA
Advanced Peptides, Inc. is a Boston area company that provides experienced design and production of custom peptides, PNA's, and antibodies. Our services cover a wide spectrum of chemistry and immunology. Our scientists have synthesized products for the scientific community for over 30 years and have met the highest standards of quality, service, and technical expertise.
Advanced Peptides was founded as a collaborative effort between a group of scientists and academic researchers from around the Boston area. Having done both peptide based research as well as peptide design and manufacturing, this group had the unique opportunity to experience both sides of the peptide industry. Designing quality peptides produced at a valued cost became the primary vision of Advanced Peptides.